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If you are interested in cryoEM and/or the Facility, please contact the following people: For general advice about using cryoEM in your research as non-expert-lab at UTSW, please  contact Dr. Diana Tomchick (director of the single particle cryoEM service-for-fee program at UTSW).

training program funded by the National Heart, Lung, and Blood Institute (NHLBI) R38 grant mechanism.

Community-Engaged Research Dissemination Community stakeholders play a vital role in disseminating research-related information to the stakeholders for whom the research is meant to inform.

In Vitro Metabolic Stability: Preclinical Pharmacology Core - UT Southwestern, Dallas, Texas In Vitro Metabolic Stability Unless a compound is a pro-drug, good metabolic stability is important for achieving therapeutic concentrations for the sufficient amount of time in vivo.

Aqueous Solubility Determination: Preclinical Pharmacology Core Lab - UT Southwestern, Dallas, Texas Aqueous Solubility Determination Poor aqueous solubility can limit the ability to develop lead compounds as in vivo probes and therapeutics.

In the “Input” tab, give Relion the script for training TOPAZ, as well as the micrographs you want TOPAZ to be trained on and the set of particles for training. d.

The activities such as method development for your project, contributing in your experimental design, helping you with data analysis, statistical analysis, pathway analysis, and interpretation of MS collected data, draft of the article or revise it should be recognized as an intellectual contribution

Caco-2 Permeability: Preclinical Pharmacology Lab - UT Southwestern, Dallas, Texas Caco-2 Permeability Caco-2 assays measure the ability of a drug to be absorbed from the gastrointestinal tract and thereby to evaluate whether the drug can be suitably dosed via an oral route.

The CPRIT award will support: Operations of the Cryo-Electron Microscopy Core Facility at UTSW by contributing to staff salaries and instrument service contracts. Purchase of new equipment to increase efficiency of cryo-sample-preparation and sample screening.

While protein binding may account for some of this discrepancy, we have on occasion noted differences in the extent to which different compounds accumulate inside of cells or the extent to which the same compound accumulates in different cells (1).